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-rw-r--r--doc/tools-doc.nix41
-rw-r--r--doc/tools.xml14
-rw-r--r--tools/bwa.nix13
-rw-r--r--tools/strelka.nix27
4 files changed, 90 insertions, 5 deletions
diff --git a/doc/tools-doc.nix b/doc/tools-doc.nix
new file mode 100644
index 0000000..b2cd7ba
--- /dev/null
+++ b/doc/tools-doc.nix
@@ -0,0 +1,41 @@
+{ bionix ? import ./.. {} }:
+
+with bionix;
+
+stage {
+ name = "tools-docs";
+ src = ../tools;
+
+ xsltFlags = lib.concatStringsSep " " [
+ #"--param section.autolabel 1"
+ #"--param section.label.includes.component.label 1"
+ #"--stringparam html.stylesheet 'style.css overrides.css highlightjs/mono-blue.css'"
+ #"--stringparam html.script './highlightjs/highlight.pack.js ./highlightjs/loader.js'"
+ #"--param xref.with.number.and.title 1"
+ #"--param toc.section.depth 3"
+ #"--stringparam admon.style ''"
+ #"--stringparam callout.graphics.extension .svg"
+ ];
+
+
+ buildInputs = with pkgs; [ nixdoc libxslt libxml2 ];
+ installPhase = ''
+ function docgen {
+ nixdoc -c "$1" -d "$2" -f "$1.nix" | sed 's/lib\./bionix./g' |grep -v locations.xml > "$1.xml"
+ }
+
+ docgen bwa 'BWA aligner'
+ docgen strelka 'Strelka2 variant caller'
+
+ mkdir $out
+ cp ${./tools.xml} tools.xml
+ xmllint --nonet --xinclude --noxincludenode tools.xml --output tools-full.xml
+ cat tools-full.xml
+ xsltproc $xsltFlags \
+ --nonet \
+ --xinclude \
+ --output $out/index.html \
+ ${pkgs.docbook_xsl_ns}/xml/xsl/docbook/epub/docbook.xsl \
+ tools-full.xml
+ '';
+}
diff --git a/doc/tools.xml b/doc/tools.xml
new file mode 100644
index 0000000..f23dfeb
--- /dev/null
+++ b/doc/tools.xml
@@ -0,0 +1,14 @@
+<book xmlns="http://docbook.org/ns/docbook"
+ xmlns:xi="http://www.w3.org/2001/XInclude">
+ <info>
+ <title>Bionix</title>
+ </info>
+ <section xmlns="http://docbook.org/ns/docbook"
+ xmlns:xlink="http://www.w3.org/1999/xlink"
+ xmlns:xi="http://www.w3.org/2001/XInclude"
+ xml:id="sec-tools">
+ <title>Tools</title>
+ <xi:include href="bwa.xml" />
+ <xi:include href="strelka.xml" />
+ </section>
+</book>
diff --git a/tools/bwa.nix b/tools/bwa.nix
index d0ab5ee..03735d1 100644
--- a/tools/bwa.nix
+++ b/tools/bwa.nix
@@ -2,7 +2,16 @@
with bionix;
-{
- align = callBionixE ./bwa-mem.nix;
+rec {
+ /* Align read against a reference: defaults to bwa-mem */
+ align = bwa-mem;
+
+ /* Align reads against a reference using bwa-mem
+ Type: bwa-mem :: {ref = fasta, bamOutput = bool, ...} -> {input1, input2} -> bam/sam
+ */
+ bwa-mem = callBionixE ./bwa-mem.nix;
+ /* Creates an reference index for BWA
+ Type: {...} -> fasta -> BWA index
+ */
index = callBionixE ./bwa-index.nix;
}
diff --git a/tools/strelka.nix b/tools/strelka.nix
index 9a8f1aa..1cf8961 100644
--- a/tools/strelka.nix
+++ b/tools/strelka.nix
@@ -4,21 +4,42 @@ with bionix;
with types;
{
+ /* Calls somatic variants
+ Type: callSomatic :: {...} -> {tumour, normal} -> somatic results
+ */
callSomatic = callBionixE ./strelka-callSomatic.nix;
+ /* Calls variants
+ Type: call :: {...} -> [input] -> results
+ */
call = callBionixE ./strelka-call.nix;
- variants = drv: stage {
+ /* Extract VCF file from results
+ Type: variants :: results -> vcf
+ */
+ variants =
+ # result of call
+ drv: stage {
name = "strelka-call-variants";
buildCommand = ''
ln -s ${drv}/variants/variants.vcf.gz $out
'';
passthru.filetype = filetype.gz (filetype.vcf {ref=ref;});
};
- indels = drv: stage {
+ /* Extract indels from somatic results
+ Type: indels :: somatic results -> vcf
+ */
+ indels =
+ # result of callSomatic
+ drv: stage {
name = "strelka-callVariants-indels";
buildCommand = "ln -s ${drv}/variants/somatic.indels.vcf.gz $out";
passthru.filetype = filetype.gz (filetype.vcf {ref = ref;});
};
- snvs = drv: stage {
+ /* Extract SNVs from somatic results
+ Type: snvs :: somatic results -> vcf
+ */
+ snvs =
+ # result of callSomatic
+ drv: stage {
name = "strelka-callVariants-snvs";
buildCommand = "ln -s ${drv}/variants/somatic.snvs.vcf.gz $out";
passthru.filetype = filetype.gz (filetype.vcf {ref = ref;});