manta: init

2 files changed, 47 insertions, 0 deletions

diff --git a/tools/manta-call.nix b/tools/manta-call.nix
new file mode 100644
index 0000000..e230a40
--- /dev/null
+++ b/tools/manta-call.nix
@@ -0,0 +1,40 @@
+{ bionix, indexAttrs ? {}, faidxAttrs ? {}, flags ? "" }:
+
+{ normals ? [], tumour ? null }:
+
+with bionix;
+with lib;
+with types;
+
+let
+  getref = matchFiletype "manta-call" { bam = x: x.ref; };
+  refs = map getref normals ++ optionals (tumour != null) [(getref tumour)];
+  ref = head refs;
+
+  renameAndIndex = f: stage {
+    name = "rename";
+    buildCommand = ''
+      mkdir $out
+      ln -s ${f} $out/sample.bam
+      ln -s ${samtools.index indexAttrs f} $out/sample.bam.bai
+    '';
+  };
+in
+
+assert (length (unique refs) == 1);
+
+stage {
+  name = "manta-call";
+  buildInputs = with pkgs; [ manta strace ];
+  buildCommand = ''
+    ln -s ${ref} ref.fa
+    ln -s ${bionix.samtools.faidx faidxAttrs ref} ref.fa.fai
+    configManta.py ${optionalString (normals != null) (concatMapStringsSep " " (n: "--bam=${renameAndIndex n}/sample.bam") normals)} \
+      ${optionalString (tumour != null) "--tumourBam=${renameAndIndex tumour}/sample.bam"} \
+      --runDir=$TMPDIR \
+      --referenceFasta=ref.fa \
+      ${flags}
+    ./runWorkflow.py
+    cp -r results $out
+  '';
+}
diff --git a/tools/manta.nix b/tools/manta.nix
new file mode 100644
index 0000000..aa8b762
--- /dev/null
+++ b/tools/manta.nix
@@ -0,0 +1,7 @@
+{ bionix }:
+
+with bionix;
+
+{
+  call = callBionix ./manta-call.nix;
+}